Esomeprazole Magnesium

Chemical Name: 5-Methoxy-2-[(S)[(4-methoxy-3,5-dimethyl-2-pyridinyl)
methyl]sulfinyl]-1H-benzimidazole magnesium salt trihydrate

Molecular Formula: C34H36MgN6O6S2•3H2OC17H18N3O3S•Na

CAS Number: 217087-09-7

Introduction
Acid- or proton-pump inhibitor; gastric antisecretory agen

Uses for Esomeprazole Magnesium
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.

Gastroesophageal Reflux (GERD)

Short-term treatment of symptomatic GERD (e.g., heartburn) in patients without erosive esophagitis. tajdrug_Gastroesophageal

Short-term treatment of erosive esophagitis (diagnostically confirmed) in patients with GERD.

Maintain healing, symptom resolution, and decrease recurrence of erosive esophagitis.

IV as short-term (≤10 days) alternative to oral therapy in patients with a history of erosive esophagitis who are unable to continue taking the drug orally.

Duodenal Ulcer
Treatment of Helicobacter pylori infection and duodenal ulcer disease (active duodenal ulcer or history of duodenal ulcer in the past 5 years). Used in conjunction with amoxicillin and clarithromycin (triple therapy).NSAIA-associated Ulcers
Reduction in the occurrence of gastric ulcers associated with chronic NSAIA therapy in patients at risk (i.e., ≥60 years of age and/or history of gastric ulcer).Effect on occurrence of duodenal ulcers not established.

Crohn’s Disease-associated Ulcers
Some evidence for use of proton-pump inhibitors (e.g., omeprazole) for gastric acid suppressive therapy as an adjunct in the management of upper GI Crohn’s disease, including esophageal, gastroduodenal, and jejunoileal disease

Esomeprazole Magnesium Dosage and Administration
Oral Administration
Administer orally at least 1 hour before a meal.
Antacids may be used concomitantly as needed for pain relief. Capsules
Swallow capsules intact; do not chew or crush.

Alternatively, open capsule and mix contents with 1 tablespoon applesauce; swallow immediately without chewing.Applesauce should not be hot and should be soft enough to swallow without chewing

Dosage
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.

Available as esomeprazole magnesium and esomeprazole sodium; dosage expressed in terms of esomeprazole

Pediatric Patients
GERD
Oral

Adolescents 12–17 years of age: 20 or 40 mg once daily for up to 8 weeks

Adults

GERD

GERD Without Erosive Esophagitis

Oral

20 mg once daily for 4 weeks; may give an additional 4 weeks of therapy.Chronic proton-pump inhibitor therapy may be appropriate

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