Simvastatin Tablet

Composition :
Simvastatin  -5
Each film-coated tablet contains Simvastatin USP 5 mg

Simvastatin  -10
Each film-coated tablet contains Simvastatin USP 10 mg

Simvastatin  -20
Each film-coated tablet contains Simvastatin USP 20 mg

Description :
Simvastatin, a cholesterol lowering agent, is a specific inhibitor of 3-hydroxy- 3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol.

Indications :
Patients with hypercholesterolaemia requiring modifications of lipid profiles

Dosage and administration :
The recommended usual starting dose is 10-40 mg once a day in the evening. The dosage range is 5-80 mg/day. Patients with homozygous familial hypercholesterolaemia The recommended dosage is simvastatin 40 mg/day in the evening or 80 mg/day in 3 divided doses of 20 mg, 20 mg, and an evening dose of 40 mg. Adolescents (10-17 years of age) with heterozygous familial hypercholesterolaemia The recommended usual starting dose is 10 mg once a day in the evening. The recommended dosing range is 10-40 mg/day; the maximum recommended dose is 40 mg/ day.

Contraindications :
* Hypersensitivity
* Active liver disease or unexplained persistent elevations of serum transaminases
* Pregnancy and lactation

Presentation
Simvastatin  -5 Blister of 10 tablets
Simvastatin  -10 Blister of 10 tablets
Simvastatin  -20 Blister of 10 tablets

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